"Today the world lost an amazing talent," said Tracy Mapes with Imperium 7 Talent Agency. She did not provide details regarding the cause of death.
His ex-wife, singer and actress Gloria Loring, confirmed his death in a statement on Facebook.
"It is a shock. We were all just together for Thanksgiving. He was talented, funny and deeply devoted to his family. Rest In Peace, dear one."
Thicke was best known for his role as Jason Seaver on the hit 1980s sitcom "Growing Pains," which aired on ABC from 1985 to 1992. But in a career spanning five decades he played various roles on and off screen, from actor to writer to composer.
"Growing Pains" launched the careers of Thicke and the actor who played his son, Kirk Cameron. Thicke went on to appear in numerous television shows and films, often appearing as himself in shows, including "How I Met Your Mother."
Thicke recently appeared on Netflix's "Fuller House," a reboot of another 1980s sitcom, featuring Bob Saget and Kirk Cameron's real-life sister, Candace Cameron Bure. Some of the last tweets on Thicke's Twitter account referenced the show.
News of his death brought tributes on social media from fans and colleagues, including "Fuller House" co-star Bob Saget and producer Jeff Franklin.
"So sad is the passing of Alan Thicke. Such a good husband, father, brother, and friend. He will be deeply missed. Rest in peace dear Alan," Saget said on Twitter.
Thicke was born in Ontario, Canada, in 1947. He began his career in Canadian television before moving behind the scenes in American television.
In the 1970s he wrote for "Fernwood 2-Night," a short-lived satirical talk show that later became "America 2-Night," and "The Richard Pryor Show." He composed the theme songs for sitcoms "Diff'Rent Strokes" and "The Facts Of Life."
He helmed a Canadian talk show, "The Alan Thicke Show," in the early 1980s but he failed to replicate that success with American audiences on "Thicke of the Night." Then, along came the most memorable role of his career.
"Loved it. Proud of it. Proud of what it stood for. I share the corny family values espoused on that show," he said in a 2010 interview with A.V. Club. "It was a great opportunity that made my life good and something that I can show to my 12-year-old now in reruns. Corny and dated as it is, it's still relatable, understandable, and he can look at it and say 'Yeah, I get it. Now I see what you did before I was born.' "
"So if that's what goes on my tombstone, I'm perfectly comfortable with it."
He is survived by his sons Brennan, Carter and "Blurred Lines" singer Robin, as well as wife Tanya.